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Antibiotics, Immunity, and Obesity
A brief, low dose of antibiotics shortly after birth can have long-lasting consequences on gut microbes in mice and lead to obesity once the rodents reach middle age. These findings, published today (August 14) in Cell, suggest that the gut microbiome may influence the development of metabolic pathways during a critical time window early in life.
Low doses of antibiotics have been used to promote animal growth in agriculture for several decades, although the mechanism underlying the drugs’ fattening effect was unclear. Martin Blaser of the New York University Langone Medical Center and his colleagues showed in a 2012 Nature paper that early-life antibiotic therapy in mice altered hormone levels and the activities of genes involved in carbohydrate and lipid metabolism.
For this latest study, Blaser and his colleagues aimed to better understand how the timing of such treatment might mediate microbial effects on host metabolism, he told The Scientist. The researchers treated two groups of mice with low doses of penicillin either shortly before pups were born or while they were weaning. A third group of pups received the antibiotic after they had been weaned. The low doses of penicillin used in the experiments were not strong enough to decrease the overall gut microbial population, although the treatment did lead to increased body fat and skewed the proportions of dominant bacterial species in the gut.
Strawberry jam doughnut
The structure of an enzyme that causes a disease similar to AIDS in monkeys was resolved in 2011 by people playing an online game about protein folding called FoldIt. While researchers had been working at solving the problem for 13 years, the gamers had it solved within three weeks.
Typing an essay due tomorrow at 3 in the morning
Anecdotes by medical practitioners"A woman came in for a baby check with her 6-month-old and she had what looked like chocolate milk in the baby’s bottle. So he started explaining to her as kindly as he could that she shouldn’t be giving her baby chocolate milk. At which point she interrupts him and says, ‘Oh that isn’t chocolate milk. It’s coffee! He just loves it!”
"I had a patient come in for an STD check. She was very upset and continued to tell me that she only had one partner. Progressing through my assessment, she further divulged that even if he was sleeping with other people it shouldn’t matter ‘because he uses a condom every time and he makes sure to wash it thoroughly after every use’.”
"Had a lady who measured her baby’s temperature by pre-heating the oven and putting one hand in front of it while the other hand was on the baby’s forehead. She told the nurse her baby’s fever was about 250 degrees.”
"Lady has to have foot amputated and is given waiver forms to sign pre-op. Buddy asks if she needs time to think about it. She’s very nonchalant and doesn’t seem to care much what they do. He gets suspicious and probes a bit as to why she’s not more concerned. She says she gets that they have to operate and it’s OK because the foot will grow back.”
"I had a couple who had been trying to conceive for over two years. I asked all the usual questions, how often do you have sex, any previous pregnancy, etc etc. Something seemed off to me during the consult, so I continued to ask questions. Finally I asked if he ejaculated while inserted into the vagina. Both parties looked confused.Turns out the couple was not having insertional sex at all. I had to awkwardly explain to them how insertional sex works. Diagrams were required.”
"Patient comes in, she’s upset. She’s pregnant, and she doesn’t understand why. She’s on the pill. Upon talking to her at great length, I find out that she only takes the pills on the days that she is sexually active – no other time.”
"Patient comes in with her bf. They are indignant, as if somehow I could’ve prevented [the pregnancy]. The problem? Well, the pills were bothering the girl’s stomach, so, being a gallant bf, he decided to start taking them instead.”
“I was explaining the treatment to the husband of a patient about to be discharged. He kept nodding and agreeing with me, but I knew it was flying over his head. Turned out a fundamental problem was that I was describing the drugs as ‘tablets’ and he had no clue what those were.”
Go read this. It’s really important.
Be kind to one another.
A simple message that unfortunately a lot of people forget.
- Mod Dawes Sr.
Baby laughing while getting shots
> Rock star doctor.
I don’t care how old he will be I’m taking my future children to him
That person is in the right field! So many pediatricians are terrible with children; you can tell this person LOVES children and taking care of them.